Table 2.

Univariate and multivariate analysis for prognostic factors in cancer-specific survival of stage III/IV CRC patients

Variables	Univariate analysis			Multivariate analysis
	HR	95% CI	p-value	HR	95% CI	p-value
Gender	0.835	0.594–1.175	0.300
Age	1.351	0.943–1.935	0.101
Tumor location	1.188	0.843–1.676	0.326
Tumor size	1.199	0.817–1.757	0.354
Tumor differentiation	0.731	0.497–1.074	0.110
Ki-67 positivity	0.914	0.629–1.328	0.638
Body mass index	0.806	0.597–1.087	0.158
Tumor invasion	1.595	1.097–2.319	0.015	1.341	0.920–1.955	0.127
Lymph node metastasis	1.426	1.136–1.789	0.002	1.430	1.158–1.766	0.001
Distant metastasis	3.507	2.425–5.071	<0.001	3.243	2.232–4.712	<0.001
Serum CEA level	1.466	1.006–2.136	0.046	1.515	1.038–2.212	0.031
Fn level	2.302	1.541–3.437	<0.001	2.222	1.483–3.329	<0.001

Abbreviations: Fn, Fusobacterium nucleatum; CRC, colorectal cancer; CEA, carcinoembryonic antigen; HR, hazard ratio; CI, confidence interval.