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. 2017 Aug 1;38(4):2096–2104. doi: 10.3892/or.2017.5866

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Copyright: © Liang et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 6. — Influence of miR-198 overexpression and silencing of Livin on A549 cell sensitivity to cisplatin. (A) Evidently the survival rate was dose-dependent, and both miRNA-198 and Livin-shRNA enhanced the sensitivity to cisplatin. (B) The proliferation curve of NC-shRNA + miRNA-198 and Livin shRNA + NC groups with the treatment of 1 µmol/l of cisplatin. The proliferation rate of the blank group was significantly higher than that of the NC-shRNA + miRNA-198 and Livin-shRNA + NC groups. However, A549 cells cotransfected with Livin-shRNA and NC had a similar effect on the sensitivity to cisplatin as miR-198 with NC-shRNA (*p<0.05).