Table I.
Comparison of TP53, TP63 and TP73 mutations in cutaneous melanomas (n=605).
| Types of mutations | TP53 | TP63 | TP73 |
|---|---|---|---|
| No. of cases with mutations | 91 | 89 | 9 |
| No. of cases with mutations/total (%) | 91/605 (15.0)a | 89/605 (14.7)b | 9/605 (1.5)a,b |
| No. of mutations | 105 | 111 | 10 |
| Type of mutations | |||
| Frameshift Del/Ins | 8 | 1 | 0 |
| Tandem mutations | 2 | 1 | 0 |
| Splice mutations | 7 | 8 | 0 |
| Single bp | 88 | 101 | 10 |
| Classes of bp, n (%) | |||
| AT>CG | 5 (6) | 0 (0) | 1 (10) |
| AT>GC | 6 (7) | 4 (4) | 1 (10) |
| AT>TA | 5 (6) | 3 (3) | 1 (10) |
| GC>AT | 65 (73) | 92 (91) | 5 (50) |
| GC>CG | 5 (6) | 1 (1) | 2 (20) |
| GC>TA | 2 (2) | 1 (1) | 0 (0) |
| Localization at CpGs, n/total (%) | 23/88 (26) | 37/101 (37) | 1/10 (10) |
| Localization at PyPy, n/total (%) | 75/88 (85) | 98/101 (97) | 8/10 (80) |
Data from cBioPortal for Cancer Genomics for cutaneous melanomas.
a
p<0.0001
b
p<0.0001. PyPy, pyrimidines.