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. 2017 Jul 28;38(4):2078–2086. doi: 10.3892/or.2017.5854

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Copyright: © Wang et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 5. — miR-616 promotes the in vivo growth and lung metastasis of H-358 cells in nude mice. (A) Overexpression of miR-616 promoted the subcutaneous growth of H-358 cells in nude mice. (B) The tumor volume and (C) tumor weight were significantly increased after overexpression of miR-616 in H-358 cells. (D) miR-616 overexpression increased the frequency of lung metastasis of H-358 cells in nude mice. (E) Incidence of lung metastasis and (F) number of lung metastatic nodules were significantly increased after overexpression of miR-616 in H-358 cells. n=5 repeats with similar results; *P<0.05 by t-test and Chi-square test.