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. 2017 Oct 1;7(8):526–540. doi: 10.1089/brain.2017.0486

FIG. 2.

FIG. 2.

Gpr88 deletion strongly reshapes the DMN pattern, defined as positive RSP cortex FC: (a) DMN pattern in the CTRL animal group. RSP cortex demonstrated strong coherent fluctuations of the BOLD signal with rostromedial ACA, TEa, and VIS areas, HPF, and thalamus. (b) Altered DMN pattern in the Gpr88−/− mouse brains is characterized by abolished FC of RSP with rostral ACA, TEa, and subcortical brain regions (HPF and TH), but strong connections mostly with the VIS area, including superior colliculus. (c) Statistically significant differences in the DMN patterns when comparing CTRL and Gpr88−/− groups (GLM, p < 0.001, corrected). The left panel shows the brain regions positively correlated with RSP for which correlations are significantly stronger in the CTRL than in the Gpr88−/− group. The right panel shows areas with FC stronger in the mutant group compared with the CTRL. The color scale at the middle indicates the corresponding T-value. BOLD, blood oxygen level-dependent; DMN, default mode network; GLM, general linear modeling.