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Schematics of inflammatory response during bone repair. Circulating monocytes differentiate into macrophages at the site of repair. Macrophages mediate bone formation by secreting trophic factors to promote differentiation of MSCs into osteoblasts and by differentiating into osteoclasts to remodel nascent bone. MSC, mesenchymal stem cell. Color images available online at www.liebertpub.com/teb
