Table 1.
Summary of Bioreactor Systems for Bone Tissue Engineering
| System | Cells | Scaffold | Outcomes (vs. static) | Source |
|---|---|---|---|---|
| Rotating wall vessel | BMSCs | Gelatin-HA | ↑Proliferation | (43) |
| ASCs | ZrO2 based ceramic/HAp | ↑Proliferation, Differentiation | (41) | |
| BMSCs | Gelatin-Coral/Hap | N.A. | (44) | |
| Spinner flasks | ASCs | PET | ↑Proliferation | (42) |
| BMSCs | Collagen | ↑Differentiation | (45) | |
| BMSCs | Silk | ↑Proliferation, Differentiation | (46) | |
| BMSCs | Silk | N.A. | (6) | |
| BMSCs | Gelatin-HA | ↑Proliferation, Differentiation | (43) | |
| BMSCs | Chitosan | ↑Proliferation, Differentiation | (47) | |
| Perfusion | Osteoblasts | Titanium | ↑Proliferation, Differentiation | (48) |
| BMSCs | Titanium/MSC-ECM | N.A. | (36) | |
| BMSCs | Si-TCP/HAp-TCP | ↑Proliferation, Differentiation | (49) | |
| BMSCs | DCB | ↑Proliferation, Differentiation | (10) | |
| BMSCs | DCB | ↑Proliferation, Differentiation | (50) | |
| ASCs | DCB | ↑Proliferation, Differentiation | (39) | |
| ASCs | DCB | N.A. | (51) |
ASC, Adipose-derived stem cell; BMSC, bone marrow mesenchymal stem cell; DCB, decellularized bone; ECM, extracellular matrix; HA, hyaluronic acid; HAp, hydroxyapatite; PET, polyethylene terephthalate; Si-TCP, silicate substituted TCP; TCP, tricalcium phosphate; ZrO2, zirconium dioxide; N.A., not applicable; ↑, increase.