Table 2. Experimental overview.

			Outcome
Exp.	Mouse strain		Survival	Clin.	Hist.	mRNA expr.	miRNA expr.	Aims
1	SCID ♀	Transfer-HI vs. Transfer HI+LO		X	X	X	X	To compare intestinal mRNA and miRNA expression profiles between transfer-colitic (received CD4+CD45RBhi T-cells) and transfer-non-colitic (received both CD4+CD45RBHI+LO T-cells) mice, at three different time points during colitis development.
2	SCID ♀	Transfer-HI vs. no cell transfer vehicle/PBS scrambled anti-miR-203 anti-miR-142-5p anti-miR-146b anti-miR-223	X	X	X			To assess clinical impact of blocking selected miRNAs in transfer-colitic mice. Controls consisted of non-colitic mice (did not receive any T-cells), Phosphate buffered saline (PBS) administration, and a scrambled anti-miRNA control compound administration (predicted not to interact with any mRNA).
3	RAG1-/- ♂	Transfer-HI scrambled vs. anti-miR-142-5p	X	X	X			To validate the clinical impact of blocking miR-142-5p in transfer-colitic mice from a different background and gender.
4	SCID ♀	Transfer-HI scrambled vs. anti-miR-142-5p				X		To assess colonic mRNA expression profiles following blocking of miR-142-5p in transfer-colitic mice.

Overview of the four transfer-colitis mouse experiments described in this study.