Table 5. Reversal of expression profile toward a healthy state after anti-miR-142-5p treatment.
| Gene symbol | Fold change anti-miR-142-5p vs scrambleda | Fold change transfer colitic mice vs non-colitic miceb | Fold change transfer colitic mice vs non-colitic micec |
|---|---|---|---|
| UP | |||
| Cyp2c55 | 28.8 | -8.1 | -4.8 |
| MAL | 17.5 | -1.2 | |
| HMGCS2 | 17.2 | -5.0 | -1.5 |
| Mettl7b | 10.4 | -2.4 | |
| Sult1a1 | 8.9 | -11.3 | -10.0 |
| Mep1a | 7.9 | -4.3 | -2.7 |
| Aldob (= Aldo2) | 6.8 | -9.0 | -5.7 |
| Aldh1a1 | 5.9 | -2.2 | -2.3 |
| Hspa1a | 5.8 | -8.4 | -19.5 |
| Edn2 | 4.9 | -3.1 | -2.5 |
| Sult1d1 | 4.8 | -10.4 | -3.6 |
| Dpep1 | 4.2 | -3.4 | -4.8 |
| DOWN | |||
| Sprr2d | -20.0 | 28.2 | 5.7 |
| Serpinb11 | -14.3 | 28.9 | |
| S100a9 | -7.8 | 168.1 | 225.4 |
| Sprr2h | -5.8 | 29.5 | 14.5 |
| Dlk1 | -5.7 | 8.1 | 4.9 |
| Sprr2b | -4.5 | 2.3 | 1.6 |
Selection of genes with potential relation to inflammatory intestinal disorders or gut physiology that are strongly up- or downregulated in colon mRNA analysis of anti-miR-142-5p-treated versus scrambled LNA treated colitic mice (2nd column). A reversed expression profile is observed when comparing transfer colitic mice to control non-colitic mice (3rd column). This reversed expression profile is also seen in data from our previously published study, also comparing transfer colitic mice to control non-colitic mice (4th column).