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. Author manuscript; available in PMC: 2017 Oct 23.
Published in final edited form as: J Med Chem. 2017 Sep 14;60(18):7928–7934. doi: 10.1021/acs.jmedchem.7b00875

Figure 4.

Figure 4

Activity of 7, 4, and 5 at the α7 nAChR. The vertical axis refers to the net charge of the compound at the given concentration co-applied with 10 µM 1, relative to 60 µM ACh controls. Experimental values are the average normalized response of at least four cells (± S.E.M.). In all cases these compounds showed less than 10% of the control ACh response when they were applied alone to the receptor.