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. Author manuscript; available in PMC: 2017 Oct 23.
Published in final edited form as: Clin Cancer Res. 2016 Feb 4;22(14):3582–3592. doi: 10.1158/1078-0432.CCR-15-1749

Figure 4.

Figure 4

Notch1 induction caused reduced tumor growth and pulmonary metastases in thyroid cancer orthotopic mouse model. (A). Representative imaging for tumor growth in both Notch-induction group (Dox+) and control group (Dox-) during different time points using IVIS. (B). Total flux (photons/sec) was obtained by IVIS for each animal. Each dot represents mean± SEM; * indicates p <0.05. (C). Representative optical imaging and microscopic view (400X) of pulmonary metastases in thyroid cancer without Notch1 induction (Dox-), which was less frequently observed in tumors with Notch1 induction (Dox+). “Dox” indicates doxycycline;Scale bar: 20μm.