Table 1.

Correlation between Notch1 expression levels and clinicopathological variables in DTC

Variables	No.	Median	25~75 percentile	p-value
Age
<45yr	17	0.505	0.323 – 0.843
>=45yr	21	0.320	0.227 – 0.476	*0.032
Gender
Male	9	0.326	0.255 – 0.514
Female	29	0.435	0.255 – 0.826	0.257
Tumor size(mm)
<20	26	0.417	0.243 – 0.739
>=20	12	0.326	0.285 – 0.633	0.790
§1Multifocality
No	20	0.498	0.271 – 0.769
Yes	18	0.317	0.254 – 0.453	0.260
§2Extrathyroidal extension
No	30	0.471	0.313 – 0.805
Yes	8	0.260	0.236 – 0.314	*0.005
Lymph node metastases
No	23	0.399	0.242 – 0.784
Yes	15	0.362	0.298 – 0.545	0.976
Distant metastases
No	37	0.366	0.256 – 0.699
Yes	1	0.320	N.A	0.789
pTNM stage
I	29	0.449	0.278 – 0.826
II,III,IV	9	0.308	0.243 – 0.384	0.066

^§1Multifocality: the presence of additional focus of thyroid carcinoma in non-tumorous part of thyroid gland

^§2Extrathyroidal extension: the extension of tumor beyond the capsule of thyroid gland

^*indicates p value is less than 0.05 which reaches statistically significant.