Fig. 5.

CXCL10 and CXCR3 mRNA expression in lung tissues of humans and ferrets infected with SARS CoV. (A) CXCL10 and (B) CXCR3 are significantly increased in the lungs of fatal outcome SARS (P < 0.05). RNA was isolated from bilateral lower lung biopsies from three deceased SARS patients and from lower lung biopsies from three control cadaveric lungs. (C) CXCL10 mRNA levels in the lungs of mock vs. SARS CoV-infected ferrets. Data represent averages from three animals per group, performed in triplicate wells. Asterisks indicate statistical significance using Mann–Whitney rank sum test (P < 0.05).