Table 3.

Aging and Neutrophils

Alterations in neutrophil function with advanced age	Reference
↓ Chemotaxis	62–69
No change in chemokinesis	62
↓ Phagocytosis	64, 66, 70–77
↓ Production of reactive oxygen species (ROS)	63, 64, 66, 72, 73, 78–80
↓ Generation of neutrophil extracellular traps (NETs)	81–83
↓ Production of pro-inflammatory cytokines and mediators, including IL-6, IL-8, myeloperoxidase, elastase and ↑ Production of anti- inflammatory cytokines, IL-10	78, 84, 85
No increase in lifespan following stimulation	85–89