Table 1.
Inflammation and nerve injury differentially affect voluntary behaviors while mice display mechanical hypersensitivity.
| Behavioral Endpoint | CFA, bilateral | SNI, unilateral |
|---|---|---|
| Mechanical withdrawal threshold | ↓ | ↓ |
| Wheel running | ↓ | no Δ |
| Gait | Δ | Δ |
| Social interaction | no Δ | no Δ |
| Open field-locomotion | ↓ | no Δ |
| Open field-anxiety | no Δ | no Δ |
↓ indicates significantly decreased behavior; Δ indicates significant behavioral changes; no Δ indicates absence of significant behavioral changes; CFA, Complete Freund’s Adjuvant; SNI, spared nerve injury.