Fig 4. The release profile of ketorolac in vitro and in vivo.

(A) In vitro assessment of cumulative ketorolac drug release from keto-hydrogel for 28 days. Inset shows the detail of ketorolac release for the initial 48 hours. (B) In vivo ketorolac concentration in tissue fluid at various time points (ketorolac solution versus keto-hydrogel; n = 3). Ketorolac concentrations are expressed as mean ± SD. *P < 0.05, **P < 0.001.