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. Author manuscript; available in PMC: 2018 Nov 1.
Published in final edited form as: Prog Retin Eye Res. 2017 Jun 7;61:60–71. doi: 10.1016/j.preteyeres.2017.06.003

Figure 1. A working hypothesis: Homeostatic control of myopia by opposing effects of D1-like and D2-like receptors in mouse eye.

Figure 1

Based on genetic and pharmacological results from mouse models of myopia, we postulate that D1-like and D2-like receptor activation in distinct cell types exert homeostatic control of the emmetropization process. The balance of D1-like and D2-like receptor activation in the eye modulates refractive eye development, such that over activation of D1-like receptors leads to hyperopia while over activation of D2-like receptors leads to myopia.