Skip to main content
. Author manuscript; available in PMC: 2018 Nov 1.
Published in final edited form as: Prog Retin Eye Res. 2017 Jun 7;61:60–71. doi: 10.1016/j.preteyeres.2017.06.003

Table 1. Dopamine receptor biology in retina: signaling, distribution and pharmacology.

The two main families of dopamine receptors are listed with their receptor subtypes and various agonists and antagonists. RP: photoreceptor; BC: bipolar cell; HC: horizontal cell; AC: amacrine cell; RGC: retinal ganglion cell; RPE: retinal pigment epithelium.

graphic file with name nihms888669u1.jpg graphic file with name nihms888669u2.jpg
D1 D5 D2 D3 D4
Retinal distribution Type-specific BCs, HCs, a set of ACs, RGCs RPE PR Dopaminergic ACs none PR (mouse)
Agonist Ki value (nM) Dopamine 0.9–2340 <0.9–261 2.8–474 4–27 28–450
Apomorphine 0.7–680 122–168 0.7–24 20–32 4
ADTN 2.9–>10000 n/a 1–1370 n/a 393
SKF-38393 1–150 0.5–100 150-9560 5000 1000–1300
PD-168077 >10000 n/a 2820-3740 2810 8.7–25
Antagonist Ki value (nM) Haloperidol 27–203 33-151 0.6–1.2 2.74-7.8 2.3–5.1
Spiperone 99–350 135-4500 0.06–0.37 0.32–0.71 0.05–4
SCH-23390 0.11–0.35 0.11-0.54 270–1100 314–800 3000–3560
Sulpiride 20400–45000 11000–77270 2.5–7.1 8–206 21–1000
L-745870 n/a n/a 960 2300 0.43
Methylergonovine n/a n/a n/a n/a n/a