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. Author manuscript; available in PMC: 2018 Dec 1.
Published in final edited form as: Neurobiol Aging. 2017 Sep 5;60:153–163. doi: 10.1016/j.neurobiolaging.2017.08.027

Figure 5.

Figure 5

Coupling of Positive and Negative Modulation to Difficulty. A significant relationship between BOLD modulation to difficulty was found between regions of positive and negative modulation, beyond the effect of age. Greater positive modulation was associated with decreased negative modulation, suggesting that up-modulating frontal-parietal regions to difficulty comes at the expense of further down-modulating deactivated regions. Modulation values reflect the slope of BOLD activation across the increasing difficulty levels and are residualized for age.