Table 1. Clinical characteristics patients with SCD without ACS and with ACS.
Patient characteristics, demographics and hematologic values
| No ACS (n =10) Median (25th, 75th) or frequency (%) |
ACS (n=23) Median (25th, 75th) or frequency (%) |
p-value | |
|---|---|---|---|
| Age, median (range), y | 14 (3–20) | 15 (8–23) | 0.18 |
| Sex, n (%) | 0.19 | ||
| Male | 8 (80) | 18 (67) | |
| Female | 2 (20) | 9 (33) | |
| Clinical Characteristics | |||
|
| |||
| Hemoglobin Genotype | 0.06 | ||
| SS | 5 | 19 | |
| SC | 4 | 3 | |
| Sb+ | 1 | 0 | |
| S-O-Arab | 0 | 1 | |
| Rate of ACS (# / year) | 0 | 0.22 (0.07, 0.3) | 0.001 |
| Absolute # ACS | 0 | 2.87 (1,4) | 0.003 |
| Rate of Pain | 0.08 (0, 0.02) | 0.40 (0, 0.62) | 0.03 |
| Absolute # Pain | 0–12 | 0–26 | 0.08 |
| Hydroxyurea | 4 (40) | 14 (60) | 0.16 |
| Asthma, # (%) | 0 (0) | 16 (70) | 0.0002 |
| OSA (%) | 3 (30) | 9 (39) | 0.28 |
| Splenectomy (%) | 1 (10) | 2 (9) | 0.46 |
| Cholecystectomy | 0 (0) | 7 (30) | 0.06 |
| Hematologic Values | |||
|
| |||
| White blood cell count (×10*3/uL) | 12.05 (9.05, 11.43) | 12.13 (9.00, 15.20) | 0.97 |
| Hemoglobin (g/dL) | 8.23 (7.53, 8.90) | 9.12 (7.83, 10.30) | 0.18 |
| MCV (fL) | 80.56 (76.00, 85.48) | 90.05 (81.98, 96.8) | 0.006 |
| Absolute retic (K/uL) | 274.4 (201.0, 303.0) | 247.3 (178.3, 331.3) | 0.47 |
| Platelet (×10*3/uL) | 425.4 (328.5, 474.5) | 364.1 (3018, 450.8) | 0.15 |
| Bilirubin (mg/dL) | 2.78 (2.25, 3.33) | 3.83 (2.00, 4.00) | 0.46 |
Results are expressed as median (25 %ile, 75 %ile). P-values: overall significance between groups. MCV: mean corpuscular volume.