Figure 3. Deletion of the T1IFNR from cardiomyocytes at 30 days p.i. has no significant impact on the prevalence or the quantity of persistent CVB3 RNA.
A. Thirty-four of the 63 hearts scored positive for viral RNA. The percentage of viral RNA+ mice in each group is shown, and the numerals indicate RNA+/total mice in each group. B. The amount of CVB3 RNA in the heart of each of the 34 RNA+ mice is shown, together with the group mean ± SE. Eight mice from the d42 groups (shown by mNN labels) were selected for further analysis. C. PCR evaluation of genomic DNA from all of the 8 selected mice confirms heart-specific and near-complete deletion of the floxed DNA fragment in Tam-treated animals.