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. Author manuscript; available in PMC: 2018 Oct 1.
Published in final edited form as: Biochim Biophys Acta. 2017 Jun 1;1863(10 Pt B):2680–2691. doi: 10.1016/j.bbadis.2017.05.027

Fig. 1.

Fig. 1

Effect of in vivo treatment with metformin on mean arterial blood pressure (A and B) and heart rate (C and D) in young and mature mice of both genders subjected to hemorrhage and resuscitation. Data represents the mean ± SD of 10 mice in each group. Vehicle (normal saline) or metformin (100 mg/kg) was administered intra-arterially at the time of resuscitation. Arrows indicate time of induction of hemorrhage and initiation of resuscitation and metformin or vehicle administration. *P<0.05 vs baseline values at time 0 of the same group; ‡P<0.05 vs young group of the same gender; #P<0.05 vs vehicle-treated group of the same age.