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. Author manuscript; available in PMC: 2019 Feb 1.
Published in final edited form as: J Steroid Biochem Mol Biol. 2017 Apr 23;176:88–93. doi: 10.1016/j.jsbmb.2017.04.011

Figure 1. Convergence of PR and Prolactin Receptor (PRLR) Signaling Interactions.

Figure 1

Prolactin and progesterone are important regulators of STAT proteins. Prolactin-induced activation of PRLR triggers several signaling cascades. For example, signaling to JAK2 kinase activates STAT5. Activation of the MAPK pathway can also lead to activation of STATs through PRLR. Progestin-induced activation of PR leads to activation of PR genes that include the downstream components of the PRLR signaling pathway (e.g. STAT5a). In addition, progesterone enhances prolactin-mediated stimulation of STAT activation in part through the JAK2 and MAPK pathways. Progesterone-induced activation of c-Src also provides a hormone-induced input to PRLR (i.e. via STAT phosphorylation) signaling.