Skip to main content
. 2017 Oct;6(5):600–610. doi: 10.21037/tlcr.2017.07.02

Figure 1.

Figure 1

Screening of NR4A2 inhibitors. (A) Transient transfection of H3118 with luciferase vector containing NR4A2 binding site (5xNuRE) showed more than 20 times higher relative luciferase activity than that of H2087 cells whose median is adjusted at 1.0 (P<0.0001, two sided, Wilcoxon rank-sum test). Columns and bars indicate mean and standard deviation, respectively; (B) high throughput drug screening was performed using FDA approved agents and Life Science Library (Life); (C) suppression of luciferase activity by candidate agents. Activity of luciferase vector containing NR4A2 binding sites (green) was compared to the one containing CRE sites (red). One sample for each of four concentrations was assessed.