Table 2.

Associations between blood biomarker measurements, NYHA class, and the primary endpoint

Associations between baseline measurements and the primary endpoint
	Univariable models a		Multivariable model b
	HR (95% CI)	p	HR (95% CI)	p
NT-proBNPc	3.10 (1.87–5.13)	<0.001	2.37 (1.39–4.02)	0.003
Hs-TnTc	1.94 (1.33–2.84)	<0.001	1.50 (0.96–2.33)	0.11
CRPc	1.55 (1.12–2.16)	0.005	1.53 (1.10–2.14)	0.013
NYHA classd	2.22 (1.41–3.50)	<0.001	2.14 (1.33–3.45)	0.003
Associations between serial measurements and the primary endpoint
	Univariable models a		Multivariable model b
	HR (95% CI)	p	HR (95% CI)	p
NT-proBNPc	4.02 (2.50–6.47)	<0.001	2.86 (1.73–4.73)	<0.001
Hs-TnTc	1.95 (1.36–2.77)	<0.001	1.26 (0.86–1.84)	0.32
CRPc	2.08 (1.50–2.87)	<0.001	1.69 (1.21–2.34)	0.001
NYHA classd	2.80 (1.83–4.28)	<0.001	2.33 (1.51–3.62)	<0.001

HR hazard ratio, CRP C-reactive protein, Hs-TnT high-sensitive cardiac troponin T, NT-proBNP N-terminal pro-B-type natriuretic peptide, NYHA New York Heart Association

^aIncluding age and gender

^bIncluding age, gender, systolic blood pressure and estimated glomerular filtration rate

^cHR per standard deviation increase in log transformed level

^dHR per 1-step increase