Table 3.
Description of patients presenting with a pathogen-specific purified mc IgG, as assessed with the Multiplexed Infectious Antigen microArray (MIAA) assay (MIAA+ patients).
| Description | Monoclonal gammopathy of undetermined significance |
Smoldering myeloma and multiple myeloma |
||||
|---|---|---|---|---|---|---|
| MIAA+ | MIAA− | P-value | MIAA+ | MIAA− | P-value | |
| Patients with MIAA data | 19 | 38 | 16 | 55 | ||
| Male sex (%) | 68.4% | 47.3% | NS | 87.5% | 54.5% | 0.019 |
| Age at diagnosis (years) | ||||||
| Median | 66.0 | 68.5 | NS | 71.1 | 63.1 | NS |
| Range | 40.6–79.0 | 31.0–97.0 | 55.2–84.0 | 42.0–87.0 | ||
| Mc IgG (g/L) | ||||||
| Median | 12.1 | 12.0 | NS | 24.4 | 17.7 | NS |
| Range | 5.0–27.0 | 4.0–28.9 | 11.0–48.0 | 8.5–68.0 | ||
| β2-Microglobulin (mg/L) | ||||||
| Median | 2.3 | 2.7 | NS | 5.5 | 2.7 | 0.040 |
| Range | 1.5–9.6 | 1.4–10.1 | 2.4–11.0 | 1.3–12.1 | ||
| Leukocytes (109/L) | ||||||
| Median | 6.7 | 7.5 | NS | 6.4 | 5.5 | NS |
| Range | 3.3–15.5 | 3.6–16.0 | 0.6–9.7 | 1.7–19.0 | ||
| Hemoglobin—g/dL | ||||||
| Median | 13.9 | 13.2 | NS | 11.3 | 11.0 | NS |
| Range | 10.0–16.0 | 8.7–16.2 | 8.0–15.5 | 7.3–15.2 | ||
| Platelets (109/L) | ||||||
| Median | 208.5 | 227.5 | NS | 196.5 | 210.0 | NS |
| Range | 124.0–318.0 | 75.0–580.0 | 15.0–309.0 | 78.0–529.0 | ||
| ISS stage III (%) | – | – | – | 53.3% | 13.6% | 0.0043 |
| DSS stage III (%) | – | – | – | 68.7% | 38.2% | 0.047 |
Statistical analysis was performed using the chi-2 test for categorical variables and the Mann–Whitney U test for continuous variables. Significant differences are indicated.
NS, not significant; ISS, International Staging System; DSS, Durie–Salmon Staging.