Figure 3.

The effect of estradiol (E2) replacement and dietary S-equol on locomotor activity during the light phase [(A), left] and dark phase [(A), right], daily activity (B), and percentage of daily activity during the light phase (C) in ovariectomized rats. Rats were ovariectomized and assigned to E2-replaced and cholesterol [vehicle (Veh)]-treated groups. These rats were fed a standard (control) diet (ConD) or an S-equol-containing diet (EqD). Values are shown as the mean ± SEM (n = 6 in each group). * and **, significant differences (P < 0.05 and P < 0.01, respectively) between the E2-replaced and Veh-treated rats fed the same diet; ^# and ^##, significant differences (P < 0.05 and P < 0.01, respectively) between the rats fed ConD and EqD with the same treatment.