Fig. 1.

Changes of body temperature (°C) over time (h) of rats treated intraperitoneally at 8:00 with 500 μL of olive oil (open squares, a) or with AUDA (b) in a dose of 5 mg/kg (closed squares), 15 mg/kg (open circles), or 30 mg/kg (open triangles). Closed circles represent normal circadian rhythm of body temperature in control rats. Sample size is indicated in parentheses. Black arrowheads represent the time of injection. Values are means ± SEM at 30-min averages. Asterisks indicate significant difference (***p < 0.001) between rats treated with AUDA in a dose of 30 mg/kg and non-treated animals