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. 2017 Jul 24;73(4):551–560. doi: 10.1007/s13105-017-0584-y

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© The Author(s) 2017

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 6 — Changes of body temperature (°C) over time (h) of rats treated intraperitoneally at 7:00 with TNF-α antibodies (50 μg/rat i.p.) and at 8:00 with AUDA in a dose of 15 mg/kg an hour before LPS (50 μg/kg i.p.) (open circles) or NaCl (open squares) administration. Closed triangles represent Tb of rats treated at 7:00 with IgG (50 μg/rat i.p.) and at 8:00 with AUDA an hour before LPS injection (both in same concentration as above). Closed circles represent normal circadian rhythm of body temperature in non-treated rats. Sample size is indicated in parentheses. Black arrowheads represent the time of injection. Values are means ± SEM at 30-min averages. Asterisks indicate significant difference (***p < 0.001) between experimental groups “TNFab/AUDA/LPS” and “IgG/AUDA/LPS”