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Clotting times after addition of dabigatran and rivaroxaban to whole blood and plasma. Whole blood was spiked in vitro with two doses of dabigatran (500 and 1000 ng/ml) or rivaroxaban (100 and 200 ng/ml). After EXTEM analysis was performed in whole blood, the sample was centrifuged, frozen and stored at −80 °C. Frozen plasma samples were thawed, and EXTEM analysis was performed. Boxplots present medians, 25–75% quartiles and 5–95% percentiles
