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The binding orientations found in molecular docking calculations facilitating C8-hydroxylation of AAII bound in human CYP1A1 (a); CYP1A2 (b); and CYP3A4 (c). AAII, heme and amino acid residues interacting ligand are shown as bold sticks and sticks, respectively. Red ribbon represents a part of the I helix (color figure online)
