Table 4.

The association between RDW and hemoglobin levels and DWGF/DCGF.

	Univariable analyses		Complete case analyses			aModels with missing imputation
	HR (95% CI)	P	bAdjusted HR (95% CI)	P		bAdjusted HR (95% CI)	P
DWGF
Increased RDW (>14.9%)
Values at 3 months after TPL	2.77 (1.84–4.16)	<0.001	1.88 (1.16–3.05)	0.01		1.75 (1.12–2.73)	0.01
cTime-averaged, 3–12 months	1.88 (1.00–3.51)	0.05	1.63 (0.84–3.17)	0.15		1.53 (0.80–2.93)	0.20
RDW increment 1%
Values at 3 months after TPL	1.27 (1.17–1.38)	<0.001	1.19 (1.07–1.33)	0.002		1.18 (1.06–1.31)	0.002
cTime-averaged, 3–12 months	1.40 (1.19–1.66)	<0.001	1.38 (1.13–1.69)	0.001		1.32 (1.08–1.62)	0.006
DCGF
Increased RDW (>14.9%)
Values at 3 months after TPL	1.85 (1.41–2.42)	<0.001	1.66 (1.20–2.30)	0.002		1.62 (1.21–2.18)	0.001
cTime-averaged, 3–12 months	1.73 (1.22–2.47)	0.002	1.59 (1.08–2.34)	0.02		1.56 (1.08–2.26)	0.02
RDW increment 1%
Values at 3 months after TPL	1.18 (1.11–1.26)	<0.001	1.17 (1.08–1.27)	<0.001	1.18 (1.09–1.27)		<0.001
cTime-averaged, 3–12 months	1.29 (1.17–1.43)	<0.001	1.23 (1.10–1.37)	<0.001	1.23 (1.10–1.37)		<0.001

HR, hazard ratio, CI, confidence interval, RDW, red cell distribution width, TPL, transplantation, DWGF, death-with-graft-function, DCGF, death-censored graft failure. ^aMultiple imputation by CART (classification and regression trees) was performed. ^bAdjusted for age (continuous, years), sex, smoking history, eGFR (categorical, <30, 30–60, ≥60), post-transplant RDW (continuous, %), hypoalbuminemia (categorical, serum albumin <3.0 g/dL), presence of acute rejection (within post-TPL 3 month), baseline diabetes mellitus, hypertension, whether induction therapy was performed, medication use of tacrolimus, donor relationship (categorical, deceased or living). ^cCalculated time-averaged values (Hemoglobin, eGFR, albumin and RDW) between 3–12 months from operation were used in the analyses. In the analyses using the time-averaged values, the mortality or graft failure cases before 12 months were not included.