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. 2017 Oct 23;7:13754. doi: 10.1038/s41598-017-14079-4

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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p65 KO chimera failed to inhibit human GBM growth in immune-deficient host. (A and B) The p65 KO and control recipient mice bone marrow was isolated and transplanted into irradiated donor nude mice. Once mice achieved 70% engraftment (chimera) in 2 weeks, U251 or PDX GBM811 cells were orthotopically implanted and followed-up for MRI at the 3-week or 8-week protocol, respectively. MRI data showing p65KO chimera failed to decrease the U251 or PDX GBM811 human tumor growth. Shown is one of the two experiments performed. Quantitative data is expressed in mean ± SD.