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. 2017 Oct 23;7:13780. doi: 10.1038/s41598-017-13845-8

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Crystal structures of IgG1-Fc/sFcγRIIIa complexes. (a) Schematic representation of N-glycans expressed on fucosylated wild-type IgG-Fc (left) and sFcγRIIIa (right) used for crystallization, showing the nomenclature of oligosaccharide residues and branches. Sugar residues that gave interpretable electron densities are surrounded by solid polygons in Fc-Asn-297 N-glycans and sFcγRIIIa-Asn-162 N-glycans, whereas those in the sFcγRIIIa-Asn-45 N-glycan are indicated by a dashed box. (b) Crystal structures of Fc fragments in complex with the bis-N-glycosylated soluble form of sFcγRIIIa: left, fucosylated wild-type IgG1-Fc; center, fucosylated Y296W IgG1-Fc; right, nonfucosylated wild-type IgG1-Fc (PDB code: 3AY4). Chain A of Fc fragment, chain B of Fc fragment, and sFcγRIIIa are colored by marine, pink, and yellow, respectively. Fucose residues are colored in red. Carbohydrate residues are represented as spheres.