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. 2017 Oct 23;7:13738. doi: 10.1038/s41598-017-14221-2

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Effect of chloroquine on the biodistribution of silicon particles. (a) Stability of ⁸⁹Zr-labeled silicon particles after 15 min in 50% mouse serum measured with a radio thin-layer chromatography (TLC) scanner. (b) Accumulation of intravenously injected ⁸⁹Zr-labeled silicon particle in the blood, liver, spleen, and lungs. BALB/c mice were pretreated with chloroquine (60 mg/kg/day for 7 days). Organs were harvested 15 min after intravenous injection of silicon particles (8 × 10⁷/mouse). (c) Blood/liver and blood/spleen accumulation ratio of ⁸⁹Zr-labeled silicon particles (g tissue). Data is presented as mean ± s.d. (n = 5). Statistics by Student’s t-test. *P < 0.05; **P < 0.01; ***P < 0.001.