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. 2017 Oct 23;7:13831. doi: 10.1038/s41598-017-14365-1

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Psoriasis and atherosclerosis have overlapping gene expression and biologic processes. (a) Using a systems biology approach, we compared global transcriptome datasets of psoriasis skin (n = 216 to post-mortem samples of carotid atherosclerotic plaque (n = 13 early stage; n = 16 advanced stage) and determined 76.9% of increased DEGs and 59.7% of decreased DEGs are observed in both tissues. (b) Further analysis utilizing Gene Ontology biological process categories demonstrated that 66 Gene Ontology biological processes are enriched in both psoriatic and advanced atherosclerotic plaque (top 30 shown, p < 0.0001), and correspond to immunological processes such as inflammatory response, response to IFN-γ, regulation of T cell activation and antimicrobial responses. The number of increased genes associated with each GO term is listed in parentheses. (c) Keratinocytes were then systematically stimulated with combinations of cytokines enriched in both psoriasis and atherosclerotic lesions determined by RNAseq. Positive statistics denote enrichment for genes induced by a given cytokine treatment, while negative statistics denote enrichment for genes repressed by a given cytokine treatment. Black bars on left highlight IFN-γ and TNF enriched signatures.