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. 2017 Oct 23;7:13831. doi: 10.1038/s41598-017-14365-1

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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TNF and IFN-γ receptors have increased expression in atherosclerosis compared to psoriasis. (a,b,c) RNAseq revealed mRNA expression of the IFN-γ is elevated in psoriasis and atherosclerotic lesions, however the IFN-γ receptors (IFNGR1, IFNGR2) TNF-α and the TNF-α receptors (TNF-RI and TNF-RII) are increased in atherosclerosis lesions compared to psoriasis, (data obtained from RNA seq and values shown as FPKM (Fragments per Kilobase of transcripts per Million mapped reads). (n = 6 lesional (PP), non-lesional (PN) and healthy (NN), n = 4 atherosclerotic (athero), n = 4 healthy vascular tissue (coronary), **p < 0.01, ***p < 0.001, two-tailed Student’s t-tests). (d) Immunohistochemistry staining of atherosclerotic lesions for IFNGR1, IFNGR2, TNF-RI and TNF-RII confirms protein expression. Data are shown as mean ± SEM with 95% CI.