Table 2.

Pearson correlation coefficient between various clinical and laboratory variables and trimethylamine N-oxide (TMAO) (n = 5,469).

	TMAO, µM		Age- and sex-adjusted
Clinical parameter	Pearson correlation	P-value	Pearson correlation	P-value
Age	0.125	<0.001	0.125 1	<0.001
Sex
M	Reference		Reference
F	−0.027	0.046	−0.0162	0.242
BMI, kg/m2	0.09	<0.001	0.068	<0.001
Smoking status
Non smoker	Reference		Reference
Current smoker	−0.040	0.003	−0.030	0.032
Hypertension	0.061	<0.001	0.007	0.668
History of CVD	0.044	0.001	0.025	0.115
T2DM	0.082	<0.001	0.075	<0.001
SBP, mmHG	0.059	<0.001	0.008	0.597
Total cholesterol, mmol/L	0.013	0.343	−0.022	0.159
HDL cholesterol, mmol/L	−0.044	0.001	−0.041	0.009
Triglycerides, mmol/L	0.044	0.001	0.022	0.158
eGFRcrea-cysC (mL/min per 1.73 m2)	−0.160	<0.001	−0.095	<0.001
UAE, mg/24 h	0.084	<0.001	0.062	<0.001

Triglycerides, UAE and TMAO were logarithmically transformed for correlation analysis. ¹Adjusted for sex. ²Adjusted for age. Abbreviations: BMI, body mass index; CVD, cardiovascular disease; eGFRcrea-cysC, estimated glomerular filtration rate based on creatinine-cystatin C equation; HDL, high density lipoproteins; SBP, systolic blood pressure; TMAO, trimethylamine N-oxide; T2DM, type 2 diabetes mellitus; UAE, urinary albumin excretion. Statistically significant correlations are shown in bold print.