Table 5.

Mediating effect of eGFR on the association of trimethylamine N-oxide (TMAO) with all-cause mortality according to Preacher and Hayes Procedure.

	Coefficient (95% CI)*	Proportion mediated
Indirect pathway (ab path)	β = 0.008, 95% CI: 0.002–0.016	15%**
Total effect (ab + c’ path)	β = 0.053, 95% CI: −0.016, 0.127

Coefficients are adjusted for age and sex. *95% CIs were bias corrected confidence intervals after running 2000 bootstrap samples. **The size of the significant mediated effect is calculated as the standardized indirect effect divided by the standardized total effect multiplied by 100.