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. 2017 Oct 23;7:13791. doi: 10.1038/s41598-017-13737-x

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Confluent monolayers of transfected cells were subjected to dispase assay. Decreased number of fragments indicates relatively enhanced cell-cell adhesion. Box and whiskers plots represent the number of fragments in six independent experiments for Dsg2 wildtype, p.D105E (p.D154E; $p < 0.001$ versus wildtype) and p.V343I (p.V392I). Box and whiskers plot: boxes extend from the 25th–75th, whiskers from the 5th–95th percentiles, the medians are shown as lines; outliers are given as dots. Means are indicated as crosses.