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. 2017 Oct 23;7:13812. doi: 10.1038/s41598-017-14195-1

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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The super network constructed based on the PLD SP. The network was established based on the PLD SP in the KEGG database³⁰ and was expanded by the addition of some pathways and neighbours via WikiPathways and data mining in the literature. As the identified pathways are shown in this figure, the FcεRI SP has been deleted from the PLD SP. LPAR4, LPAR6, GRM5, HCRTR1, and EGFR are the known receptors in this network. Different genes involved in the PLD SP and other related pathways are presented as coloured boxes. Yellow and pink colours indicate NSCLC- and SM-specific proteins in significant pathways found in this study, respectively. Brown and plum colours correspond to proteins from the NSCLC and SM protein datasets, respectively. Additionally, blue and yellow ribbons show common proteins and pathways between the two groups, respectively.