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. 2017 Oct 23;7:13741. doi: 10.1038/s41598-017-14096-3

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Signalling of AZ1729 is unaffected by mutation of Lys⁶⁵ in hFFA2. The ability of varying concentrations of AZ1729 to regulated cAMP levels (), promote binding of [³⁵S]GTPγS () and promote production of inositol monophosphates (●) in cells or membranes induced to express hFFA2 is illustrated (a). (b) AZ1729 is unable to promote inositol monophosphate production via Lys⁶⁵Arg hFFA2 (○), Lys⁶⁵Ala hFFA2 (□) or Lys⁶⁵Glu (△) hFFA2. (c,d) Potency of AZ1729 is unaffected at Lys⁶⁵Arg hFFA2 (○), Lys⁶⁵Ala hFFA2 (□) or Lys⁶⁵Glu (△) hFFA2 in [³⁵S]GTPγS (c) or cAMP inhibition (d) studies.

Inline graphic — Signalling of AZ1729 is unaffected by mutation of Lys⁶⁵ in hFFA2. The ability of varying concentrations of AZ1729 to regulated cAMP levels (), promote binding of [³⁵S]GTPγS () and promote production of inositol monophosphates (●) in cells or membranes induced to express hFFA2 is illustrated (a). (b) AZ1729 is unable to promote inositol monophosphate production via Lys⁶⁵Arg hFFA2 (○), Lys⁶⁵Ala hFFA2 (□) or Lys⁶⁵Glu (△) hFFA2. (c,d) Potency of AZ1729 is unaffected at Lys⁶⁵Arg hFFA2 (○), Lys⁶⁵Ala hFFA2 (□) or Lys⁶⁵Glu (△) hFFA2 in [³⁵S]GTPγS (c) or cAMP inhibition (d) studies.