Figure 1.

Algorithm for ProMisE molecular classifier. A sample is tested for MMR deficiency by IHC for the presence or absence of MSH6 and PMS2 proteins, sequencing is performed for exons 9–14 of the POLE exonuclease domain (EDM), and IHC for p53 performed to identify complete loss/null (IHC score 0), accumulation/missense (IHC score 2), or normal expression/wt (IHC score 1) yielding four molecular subtypes with distinct clinical outcomes. Reproduced with permission from 10.