Fig. 2.

Whole exome sequencing analysis of HCC1 and HCC2. a Flowchart of the whole exome sequencing process. Nonsynonymous mutations were extracted from HCC1 and HCC2 cells. Boxes refer to major bioinformatic processes. Variants were filtered for their coding localization, annotation in dbSNP or 1000 genomes, and somatic and functional impairment. b The major pathways in which genetic mutations were detected in HCC1 and HCC2 cells. Somatic mutations detected in HCC1 or HCC2 are shown in red or blue, respectively. Mutations detected in both HCC1 and HCC2 are shown in purple