Table 3.
Previously unpublished frameshift and nonsense mutations
| Gene | Position | Mutation type | Mutant allele (%) in EpCAM+ CSCs fraction | Mutant allele (%) in EpCAM− non-CSCs fraction | Difference (%) EpCAM+ (%) − EpCAM− (%) |
Sample |
|---|---|---|---|---|---|---|
| PCDH18 | c.2556_2557delTG | Frameshift | 67.7 | 45.9 | 21.8 | HCC 1 |
| KIAA2026 | c.1411delC | Frameshift | 34.4 | 19.6 | 14.8 | HCC 1 |
| ALKBH3 | c.182delA | Frameshift | 68.4 | 54.5 | 13.9 | HCC 1 |
| CCDC168 | c.13741G>A | Nonsense | 33.2 | 28.9 | 4.3 | HCC 2 |
| CYP2R1 | c.881_882insG | Frameshift | 38.7 | 38.4 | 0.3 | HCC 2 |
| PER1 | c.709G>A | Nonsense | 100 | 100 | 0 | HCC 1 |
| OSCP1 | c.401_402insC | Frameshift | 94.3 | 95.2 | − 1 | HCC 2 |
| ITGB8 | c.391delG | Frameshift | 74.2 | 80 | − 5.8 | HCC 2 |
| INTS12 | c.914_917delGAAG | Frameshift | 25.5 | 33 | − 7.5 | HCC 1 |
| TECTA | c.5455A>T | Nonsense | 60.1 | 68.2 | − 8 | HCC 2 |
| MKI67 | c.2101C>A | Nonsense | 23.6 | 33 | − 9.4 | HCC 1 |
| TRIP4 | c1693_1694delAA | Frameshift | 28.9 | 38.5 | − 9.6 | HCC 2 |
| CSMD1 | c6711_6712delTG | Frameshift | 86 | 100 | − 14 | HCC 2 |