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. 2017 Oct 23;16:422. doi: 10.1186/s12936-017-2062-y

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© The Author(s) 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — PG and CG uptake by MATE1 and MATE2-K. Uptake of 100 µM PG for 5 min for MATE1 (430 ± 110 pmol/mg/min) and MATE2-K (360 ± 90 pmol/mg/min) compared to the control (300 ± 40 pmol/mg/min) in HEK293 transduced cells (a). Following co-transduction of eYFP and OCT1, after measuring uptake of 1 μM PG during 1 min incubation, PG was taken up for 850 ± 60% as compared to eYFP control cells. MATE1 was not capable of reducing OCT1-mediated PG uptake by exporting this anti-malarial, however, MATE2-K reduced PG uptake to 470 ± 80% of control, which is a relative decrease of 44% in uptake (b). Uptake of 100 µM CG for 5 min was significantly higher for MATE1 (40 ± 9 pmol/mg/min) and MATE2-K (56 ± 15 pmol/mg/min) compared to the control (11.8 ± 0.9 pmol/mg/min) (c). *p < 0.05, **p < 0.01, ***p < 0.001