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. 2017 Oct 23;9:117. doi: 10.1186/s13148-017-0416-5

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© The Author(s). 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — Effects of PAE on the fractional synthesis of linker histone peptides in frontal cortex and hypothalamus of rat brain. We measured the incorporation of ²H in the following histone variant peptides H1 (rAkAAkkSTDHPkYSDMIVAAIQAEkNR), H1.1 (sGVSLAALkkSLAAAGYDVEkNNSR), H1.4 (sGVSLAALkkSLAAAGYDVEkNNSR), and H1.5 (kATGPPVSELITkAVSASkER) in frontal cortex (a) and hypothalamus (b) of 6 days old rat pups following a 5-day alcohol feeding and administration of ²H₂O. Histone Fractional Synthesis Rate (FSR) was calculated and data are shown as mean ± SE, n = 4 per group, *p < 0.05, ***p < 0.001, AF vs PF