Table 3.
DFS according to patient and tumor characteristics between WBI alone and WBI+SCNRT
| Characteristic | 5-Yr DFS (%) |
HR (95% CI) | ||
|---|---|---|---|---|
| WBI alone | WBI+SCNRT | p-valuea) | ||
| Age (yr) | ||||
| ≤ 40 | 93.6 | 88.3 | 0.27 | 1.52 (0.45-5.21) |
| > 40 | 94.5 | 94.3 | 1.13 (0.53-2.41) | |
| Tumor size (mm) | ||||
| ≤ 20 | 96.0 | 96.1 | 0.15 | 1.03 (0.31-3.31) |
| > 20 | 92.9 | 89.9 | 1.34 (0.63-2.89) | |
| No. of tumors | ||||
| Single | 94.1 | 92.4 | 0.46 | 1.29 (0.67-2.49) |
| Multiple | 95.6 | 97.5 | 0.62 (0.04-6.01) | |
| LVI | ||||
| Negative | 96.2 | 97.1 | 0.09 | 0.32 (0.04-2.96) |
| Positive | 93.6 | 91.5 | 1.45 (0.73-2.85) | |
| HG | ||||
| 1, 2 | 96.1 | 96.3 | 0.06 | 0.79 (0.28-2.23) |
| 3 | 91.9 | 88.7 | 1.64 (0.71-3.78) | |
| Molecular subtype | ||||
| Luminal A | 97.0 | 96.2 | 0.17 | 0.98 (0.31-3.06) |
| Non-luminal A | 91.7 | 90.5 | 1.31 (0.59-2.83) | |
| No. of positive nodes | ||||
| 1, 2 | 95.2 | 93.5 | 0.64 | 1.51 (0.71-3.19) |
| 3 | 91.5 | 91.9 | 0.71 (0.20-2.51) | |
| Ratio of LN (+)b) | ||||
| ≤ 0.1 | 96.8 | 95.4 | 0.06 | 1.29 (0.36-4.69) |
| > 0.1 | 92.2 | 91.4 | 1.14 (0.55-2.38) | |
DFS, disease-free survival; WBI, whole-breast irradiation; WBI+SCNRT, WBI with supraclavicular lymph node radiotherapy; HR, hazard ratio; CI, confidence interval; LVI, lymphovascular invasion; HG, histologic grade; LN, lymph node.
a)
The logrank test was used to compare survival between groups,
b)
Ratio of positive LNs to total dissected LNs.