Table 3.
Relationships of RET fusion gene arrangement with variables
| Variable |
RET fusion |
BRAF mutation |
||||
|---|---|---|---|---|---|---|
| Negative (n=216) | Positive (n=24) | p-value | Negative (n=50) | Positive (n=190) | p-value | |
| Age (yr) | ||||||
| < 45 | 94 (43.5) | 16 (66.7) | 0.031* | 28 (56.0) | 82 (43.2) | 0.105 |
| ≥ 45 | 122 (56.5) | 8 (33.3) | 22 (44.0) | 108 (56.8) | ||
| Sex | ||||||
| Male | 57 (26.4) | 8 (33.3) | 0.468 | 13 (36.0) | 52 (27.4) | 0.846 |
| Female | 159 (73.6) | 16 (66.7) | 37 (74.0) | 138 (72.6) | ||
| N stage | ||||||
| N1a | 132 (61.1) | 7 (29.2) | 0.003* | 26 (52.0) | 113 (59.5) | 0.341 |
| N1b | 84 (38.9) | 17 (70.8) | 24 (48.0) | 77 (40.5) | ||
| RET | ||||||
| Fusion (+) | - | - | - | 11 (22.0) | 13 (6.8) | 0.001* |
| Fusion (–) | - | - | - | 39 (78.0) | 177 (93.2) | |
| BRAF | ||||||
| Mutation (+) | 177 (81.9) | 13 (54.2) | 0.001* | - | - | - |
| Mutation (–) | 39 (18.1) | 11 (45.8) | - | - | - | |
| PIK3CA | ||||||
| Mutation (+) | 152 (70.4) | 19 (79.2) | 0.366 | 33 (66.0) | 138 (72.6) | 0.357 |
| Mutation (–) | 64 (29.6) | 5 (20.8) | 17 (34.0) | 52 (27.4) | ||
| NTKR1/3 | ||||||
| Fusion (+) | 6 (2.8) | 0 | > 0.990 | 2 (4.0) | 4 (2.1) | 0.607 |
| Fusion (–) | 210 (97.2) | 24 (100) | 48 (96.0) | 186 (97.9) | ||
Values are presented as number (%).
*
p < 0.05.