Table 3.
Adverse effects
| Adverse effect | Afatinib+Simvastatin |
Afatinib |
||
|---|---|---|---|---|
| ≥ Grade 3 | Total grade | ≥ Grade 3 | Total grade | |
| AST/ALT increased | 1 (2.8) | 4 (11.1) | 0 | 1 (3.1) |
| Creatinine increased | 0 | 4 (11.1) | 1 (3.1) | 7 (21.9) |
| QT prolonged | 0 | 6 (16.7) | 1 (3.1) | 4 (12.5) |
| Fatigue | 0 | 10 (27.8) | 1 (3.1) | 11 (34.4) |
| Anorexia | 1 (2.8) | 11 (30.6) | 0 | 14 (43.8) |
| Weight loss | 0 | 2 (5.6) | 0 | 6 (18.8) |
| Diarrhea | 2 (5.6) | 23 (63.9) | 6 (18.8) | 27 (84.4) |
| Stomatitis | 0 | 24 (66.7) | 2 (6.3) | 25 (78.1) |
| Dry skin | 0 | 7 (19.4) | 0 | 6 (18.8) |
| Pruritus | 0 | 15 (41.7) | 0 | 11 (34.4) |
| Skin rash | 1 (2.8) | 28 (77.8) | 1 (3.1) | 25 (78.1) |
| Paronychia | 0 | 4 (11.1) | 0 | 4 (12.5) |
| Hand-foot syndrome | 0 | 5 (13.9) | 0 | 5 (15.6) |
| Esophageal ulcer | 1 (2.8) | 1 (2.8) | 0 | 0 |
| Idiopathic bilateral vocal cord palsy | 0 | 0 | 1 (3.1) | 1 (3.1) |
AST, aspartate aminotransferase; ALT, alanine transaminase.